Voxel‐based morphometry detects cortical atrophy in the Parkinson variant of multiple system atrophy
Identifieur interne : 001682 ( Main/Exploration ); précédent : 001681; suivant : 001683Voxel‐based morphometry detects cortical atrophy in the Parkinson variant of multiple system atrophy
Auteurs : Christian Brenneis [Autriche] ; Klaus Seppi [Autriche] ; Michael F. Schocke [Autriche] ; Jörg Müller [Autriche] ; Elisabeth Luginger [Autriche] ; Sylvia Bösch [Autriche] ; Wolfgang N. Löscher [Autriche] ; Christian Büchel [Allemagne] ; Werner Poewe [Autriche] ; Gregor K. Wenning [Autriche]Source :
- Movement Disorders [ 0885-3185 ] ; 2003-10.
English descriptors
Abstract
To determine magnetic resonance imaging (MRI) patterns of brain atrophy in parkinsonian syndromes, we applied voxel‐based morphometry (VBM) to segmented gray matter, white matter, and cerebrospinal fluid compartments of T1‐weighted brain volumes of 12 patients with probable multiple system atrophy–parkinson variant (MSA‐P) and 12 Parkinson's disease patients, comparing them with 12 normal controls matched for age. In comparison to controls, a cortical atrophy pattern was observed in MSA‐P patients with significant clusters of volume loss in primary sensorimotor cortices bilateral, supplementary motor areas bilateral, right premotor cortex, prefrontal cortex bilateral (middle frontal gyri) and insular cortices bilateral; subcortical atrophy occurred bilaterally in caudate nuclei and putamen as well as in the midbrain. Furthermore, an enlargement of the cerebrospinal fluid compartment was found in the lateral ventricles, third ventricle, perimesencephalic and cerebellomedullar cavities. In PD patients, significant atrophy only occurred in left caudate head with enlargement of left lateral ventricle. Comparing MSA‐P to PD patients, MSA‐P showed a similar cortical pattern of atrophy as compared to controls. We conclude that VBM reveals selective cortical atrophy in patients with MSA‐P affecting primary and higher order motor areas as well as prefrontal and insular cortices. Further studies are required to determine clinical and/or subclinical correlates of cortical atrophy in MSA‐P. © 2003 Movement Disorder Society
Url:
DOI: 10.1002/mds.10502
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Voxel‐based morphometry detects cortical atrophy in the Parkinson variant of multiple system atrophy</title><author><name sortKey="Brenneis, Christian" sort="Brenneis, Christian" uniqKey="Brenneis C" first="Christian" last="Brenneis">Christian Brenneis</name></author><author><name sortKey="Seppi, Klaus" sort="Seppi, Klaus" uniqKey="Seppi K" first="Klaus" last="Seppi">Klaus Seppi</name></author><author><name sortKey="Schocke, Michael F" sort="Schocke, Michael F" uniqKey="Schocke M" first="Michael F." last="Schocke">Michael F. Schocke</name></author><author><name sortKey="Muller, Jorg" sort="Muller, Jorg" uniqKey="Muller J" first="Jörg" last="Müller">Jörg Müller</name></author><author><name sortKey="Luginger, Elisabeth" sort="Luginger, Elisabeth" uniqKey="Luginger E" first="Elisabeth" last="Luginger">Elisabeth Luginger</name></author><author><name sortKey="Bosch, Sylvia" sort="Bosch, Sylvia" uniqKey="Bosch S" first="Sylvia" last="Bösch">Sylvia Bösch</name></author><author><name sortKey="Loscher, Wolfgang N" sort="Loscher, Wolfgang N" uniqKey="Loscher W" first="Wolfgang N." last="Löscher">Wolfgang N. Löscher</name></author><author><name sortKey="Buchel, Christian" sort="Buchel, Christian" uniqKey="Buchel C" first="Christian" last="Büchel">Christian Büchel</name></author><author><name sortKey="Poewe, Werner" sort="Poewe, Werner" uniqKey="Poewe W" first="Werner" last="Poewe">Werner Poewe</name><affiliation><country>Autriche</country><placeName><settlement type="city">Innsbruck</settlement><region nuts="2" type="region">Tyrol (Land)</region></placeName><orgName type="university">Université de médecine d'Innsbruck</orgName></affiliation></author><author><name sortKey="Wenning, Gregor K" sort="Wenning, Gregor K" uniqKey="Wenning G" first="Gregor K." last="Wenning">Gregor K. Wenning</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:A06B06831AA8F4002B33D63B3538801B0E94A7A7</idno><date when="2003" year="2003">2003</date><idno type="doi">10.1002/mds.10502</idno><idno type="url">https://api.istex.fr/document/A06B06831AA8F4002B33D63B3538801B0E94A7A7/fulltext/pdf</idno><idno type="wicri:Area/Main/Corpus">002099</idno><idno type="wicri:Area/Main/Curation">001D98</idno><idno type="wicri:Area/Main/Exploration">001682</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Voxel‐based morphometry detects cortical atrophy in the Parkinson variant of multiple system atrophy</title><author><name sortKey="Brenneis, Christian" sort="Brenneis, Christian" uniqKey="Brenneis C" first="Christian" last="Brenneis">Christian Brenneis</name><affiliation wicri:level="1"><country xml:lang="fr">Autriche</country><wicri:regionArea>Department of Neurology, University Hospital, Innsbruck</wicri:regionArea><wicri:noRegion>Innsbruck</wicri:noRegion></affiliation></author><author><name sortKey="Seppi, Klaus" sort="Seppi, Klaus" uniqKey="Seppi K" first="Klaus" last="Seppi">Klaus Seppi</name><affiliation wicri:level="1"><country xml:lang="fr">Autriche</country><wicri:regionArea>Department of Neurology, University Hospital, Innsbruck</wicri:regionArea><wicri:noRegion>Innsbruck</wicri:noRegion></affiliation></author><author><name sortKey="Schocke, Michael F" sort="Schocke, Michael F" uniqKey="Schocke M" first="Michael F." last="Schocke">Michael F. Schocke</name><affiliation wicri:level="1"><country xml:lang="fr">Autriche</country><wicri:regionArea>Department of Radiology, University Hospital, Innsbruck</wicri:regionArea><wicri:noRegion>Innsbruck</wicri:noRegion></affiliation></author><author><name sortKey="Muller, Jorg" sort="Muller, Jorg" uniqKey="Muller J" first="Jörg" last="Müller">Jörg Müller</name><affiliation wicri:level="1"><country xml:lang="fr">Autriche</country><wicri:regionArea>Department of Neurology, University Hospital, Innsbruck</wicri:regionArea><wicri:noRegion>Innsbruck</wicri:noRegion></affiliation></author><author><name sortKey="Luginger, Elisabeth" sort="Luginger, Elisabeth" uniqKey="Luginger E" first="Elisabeth" last="Luginger">Elisabeth Luginger</name><affiliation wicri:level="1"><country xml:lang="fr">Autriche</country><wicri:regionArea>Department of Neurology, University Hospital, Innsbruck</wicri:regionArea><wicri:noRegion>Innsbruck</wicri:noRegion></affiliation></author><author><name sortKey="Bosch, Sylvia" sort="Bosch, Sylvia" uniqKey="Bosch S" first="Sylvia" last="Bösch">Sylvia Bösch</name><affiliation wicri:level="1"><country xml:lang="fr">Autriche</country><wicri:regionArea>Department of Neurology, University Hospital, Innsbruck</wicri:regionArea><wicri:noRegion>Innsbruck</wicri:noRegion></affiliation></author><author><name sortKey="Loscher, Wolfgang N" sort="Loscher, Wolfgang N" uniqKey="Loscher W" first="Wolfgang N." last="Löscher">Wolfgang N. Löscher</name><affiliation wicri:level="1"><country xml:lang="fr">Autriche</country><wicri:regionArea>Department of Neurology, University Hospital, Innsbruck</wicri:regionArea><wicri:noRegion>Innsbruck</wicri:noRegion></affiliation></author><author><name sortKey="Buchel, Christian" sort="Buchel, Christian" uniqKey="Buchel C" first="Christian" last="Büchel">Christian Büchel</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, University Hospital, Eppendorf, Hamburg</wicri:regionArea><placeName><settlement type="city">Hambourg</settlement><region type="land" nuts="2">Hambourg</region></placeName></affiliation></author><author><name sortKey="Poewe, Werner" sort="Poewe, Werner" uniqKey="Poewe W" first="Werner" last="Poewe">Werner Poewe</name><affiliation wicri:level="1"><country xml:lang="fr">Autriche</country><wicri:regionArea>Department of Neurology, University Hospital, Innsbruck</wicri:regionArea><wicri:noRegion>Innsbruck</wicri:noRegion><placeName><settlement type="city">Innsbruck</settlement><region nuts="2" type="region">Tyrol (Land)</region></placeName><orgName type="university">Université de médecine d'Innsbruck</orgName></affiliation></author><author><name sortKey="Wenning, Gregor K" sort="Wenning, Gregor K" uniqKey="Wenning G" first="Gregor K." last="Wenning">Gregor K. Wenning</name><affiliation wicri:level="1"><country xml:lang="fr">Autriche</country><wicri:regionArea>Department of Neurology, University Hospital, Innsbruck</wicri:regionArea><wicri:noRegion>Innsbruck</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2003-10">2003-10</date><biblScope unit="volume">18</biblScope><biblScope unit="issue">10</biblScope><biblScope unit="page" from="1132">1132</biblScope><biblScope unit="page" to="1138">1138</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">A06B06831AA8F4002B33D63B3538801B0E94A7A7</idno><idno type="DOI">10.1002/mds.10502</idno><idno type="ArticleID">MDS10502</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>cortical atrophy</term><term>multiple system atrophy</term><term>voxel‐based morphometry</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">To determine magnetic resonance imaging (MRI) patterns of brain atrophy in parkinsonian syndromes, we applied voxel‐based morphometry (VBM) to segmented gray matter, white matter, and cerebrospinal fluid compartments of T1‐weighted brain volumes of 12 patients with probable multiple system atrophy–parkinson variant (MSA‐P) and 12 Parkinson's disease patients, comparing them with 12 normal controls matched for age. In comparison to controls, a cortical atrophy pattern was observed in MSA‐P patients with significant clusters of volume loss in primary sensorimotor cortices bilateral, supplementary motor areas bilateral, right premotor cortex, prefrontal cortex bilateral (middle frontal gyri) and insular cortices bilateral; subcortical atrophy occurred bilaterally in caudate nuclei and putamen as well as in the midbrain. Furthermore, an enlargement of the cerebrospinal fluid compartment was found in the lateral ventricles, third ventricle, perimesencephalic and cerebellomedullar cavities. In PD patients, significant atrophy only occurred in left caudate head with enlargement of left lateral ventricle. Comparing MSA‐P to PD patients, MSA‐P showed a similar cortical pattern of atrophy as compared to controls. We conclude that VBM reveals selective cortical atrophy in patients with MSA‐P affecting primary and higher order motor areas as well as prefrontal and insular cortices. Further studies are required to determine clinical and/or subclinical correlates of cortical atrophy in MSA‐P. © 2003 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Autriche</li></country><region><li>Hambourg</li><li>Tyrol (Land)</li></region><settlement><li>Hambourg</li><li>Innsbruck</li></settlement><orgName><li>Université de médecine d'Innsbruck</li></orgName></list><tree><country name="Autriche"><noRegion><name sortKey="Brenneis, Christian" sort="Brenneis, Christian" uniqKey="Brenneis C" first="Christian" last="Brenneis">Christian Brenneis</name></noRegion><name sortKey="Bosch, Sylvia" sort="Bosch, Sylvia" uniqKey="Bosch S" first="Sylvia" last="Bösch">Sylvia Bösch</name><name sortKey="Loscher, Wolfgang N" sort="Loscher, Wolfgang N" uniqKey="Loscher W" first="Wolfgang N." last="Löscher">Wolfgang N. Löscher</name><name sortKey="Luginger, Elisabeth" sort="Luginger, Elisabeth" uniqKey="Luginger E" first="Elisabeth" last="Luginger">Elisabeth Luginger</name><name sortKey="Muller, Jorg" sort="Muller, Jorg" uniqKey="Muller J" first="Jörg" last="Müller">Jörg Müller</name><name sortKey="Poewe, Werner" sort="Poewe, Werner" uniqKey="Poewe W" first="Werner" last="Poewe">Werner Poewe</name><name sortKey="Schocke, Michael F" sort="Schocke, Michael F" uniqKey="Schocke M" first="Michael F." last="Schocke">Michael F. Schocke</name><name sortKey="Seppi, Klaus" sort="Seppi, Klaus" uniqKey="Seppi K" first="Klaus" last="Seppi">Klaus Seppi</name><name sortKey="Wenning, Gregor K" sort="Wenning, Gregor K" uniqKey="Wenning G" first="Gregor K." last="Wenning">Gregor K. Wenning</name></country><country name="Allemagne"><region name="Hambourg"><name sortKey="Buchel, Christian" sort="Buchel, Christian" uniqKey="Buchel C" first="Christian" last="Büchel">Christian Büchel</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001682 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001682 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= ParkinsonV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:A06B06831AA8F4002B33D63B3538801B0E94A7A7
|texte= Voxel‐based morphometry detects cortical atrophy in the Parkinson variant of multiple system atrophy
}}
| This area was generated with Dilib version V0.6.23. |  |